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ccRCC exemplifies this complexity: HIF-2 stabilization induces glycolysis via pyruvate dehydrogenase kinase (PDK)-mediated suppression of oxidative phosphorylation (OXPHOS), while simultaneously upregulating glutamine transporters to fuel reductive carboxylationa metabolic bypass sustaining lipid biosynthesis under hypoxia [19, 20]

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A proprietary herbal drug young yum pill ameliorates chronic fatigue syndrome in mice